For horses
TB-500 for Horses
TB-500 is the synthetic version of thymosin beta-4's active region (the LKKTETQ fragment). It's the peptide with the longest track record around horses, and thymosin beta-4 research covers cell migration, wound closure and tissue repair. Order American-made TB-500 with a verified lot COA.
What it is
The acetylated fragment of thymosin beta-4.
Esposito et al. (2012) identified TB-500 as the N-terminal acetylated 17-23 fragment of thymosin beta-4. That LKKTETQ segment is the actin-binding site tied to cell migration and tissue repair (Ho et al., 2012). Browse peptides for horses or the full equine recovery research article. Compare pathways on BPC-157 vs TB-500 for horses and peptides vs equine joint supplements.
Horse history
A long barn track record.
A 2013 Racing Medication & Testing Consortium bulletin documents TB-500 being marketed for horses for muscle and soft-tissue recovery. That history is why horse people still lead the peptide conversation — and why verified sourcing matters when you order.
Thymosin beta-4 research
The tissue research behind the fragment.
Malinda et al. (1999) reported thymosin beta-4 accelerated wound closure in rats. Philp and Kleinman (2010) reviewed animal studies across tissue types. Goldstein et al. (2012) framed thymosin beta-4 as a multifunctional regenerative peptide.
Biçer et al. (2026) compared BPC-157, TB-500 and the combination in rat Achilles: the TB-500 group had a significantly higher maximum load to failure versus control, and the combination arm showed no added benefit over monotherapy.
Equine studies
Horses in the published literature.
Ho et al. (2012) gave TB-500 to horses and mapped the peptide and its metabolites in plasma and urine. A 2025 Drug Test Anal population study shows Tβ4 is strongly conserved and abundant across mammals, including horses.
A company-reported VetBioLogix observational study ran injectable BPC-157 and TB-500 in 11 adult horses for 40 days and reported no adverse events through follow-up.
Community
What owners and barns report.
Owner forums describe TB-500 — often with BPC-157 — during layup, soft-tissue rehab and senior-horse programs. Performance barns use the pair alongside existing joint and rehab plans. After bad experiences with unverified products, owners look for COA-verified sources. See the Wolverine stack for horses when you want both peptides together.
Pricing
TB-500 price for horse owners.
| Item | Price | Note |
|---|---|---|
| TB-500 5 mg | $89.99 | Single vial |
| TB-500 10 mg | $129.00 | Most common horse size |
| Recovery Stack (BPC-157 5 mg + TB-500 5 mg) | $129.99 | Both peptides, one COA |
Subscribe & save up to 20% on longer rehab plans. Free US shipping at $200+. >99% purity on every lot — see Quality or the COA PDF.
References
- Esposito S et al. Drug Test Anal. 2012. PMID 22962027
- Malinda KM et al. J Invest Dermatol. 1999. PMID 10469335
- Philp D, Kleinman HK. Ann N Y Acad Sci. 2010. PMID 20536453
- Goldstein AL et al. Expert Opin Biol Ther. 2012. PMID 22074294
- Ho EN et al. J Chromatogr A. 2012. PMID 23084823
- Drug Test Anal. 2025. PMID 39314109
- Biçer O et al. Jt Dis Relat Surg. 2026. PMID 42542926
Buying questions
What is TB-500 used for in horses?
Horse owners order TB-500 for soft-tissue recovery, layup and rehab support. It is the synthetic version of thymosin beta-4's active region, with the longest barn history among recovery peptides and published equine administration studies.
Is TB-500 the same as thymosin beta-4?
No. Thymosin beta-4 is a 43-amino-acid protein the body makes naturally. TB-500 is the synthetic N-terminal acetylated 17-23 fragment (Ac-LKKTETQ) identified by Esposito et al. (2012). Most of the tissue-repair biology comes from the parent protein's animal studies.
Has TB-500 been studied in horses?
Yes. Ho et al. (2012) administered TB-500 to horses and mapped it in plasma and urine. A 2025 Drug Test Anal population study covers equine Tβ4. A company-reported VetBioLogix observational study used BPC-157 with TB-500 in 11 adult horses.
How much does TB-500 cost?
TB-500 is $89.99 for 5 mg and $129.00 for 10 mg. The Recovery Stack puts TB-500 5 mg with BPC-157 5 mg in one vial for $129.99. Free US shipping starts at $200.
Can TB-500 be paired with BPC-157?
Yes. That pairing is the Wolverine stack. Shop the Recovery Stack for both in one vial, or see the Wolverine stack for horses guide for the combined research and the 11-horse study.
Where can I buy TB-500 for horses?
Order American-made TB-500 at Pure Pet Peptide with a COA on every lot. Start from this page, the peptides for horses hub, or the TB-500 product page.